Article 8418

Title of the article

STUDY OF THE STELINOL PLANT EFFECT ON THE SURVIVAL AND PSYCHO-EMOTIONAL RAT BACKGROUND IN THE
CONDITIONS OF EXPERIMENTAL METABOLIC SYNDROME 

Authors

Kurdyukov Evgeniy Evgen'evich, Senior lecturer, sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: e.e.kurdyukov@mail.ru
Moiseeva Inessa Yakovlevna, Doctor of medical sciences, professor, head of the sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: moiseeva_pharm@mail.ru
Vodop'yanova Ol'ga Aleksandrovna, Candidate of medical sciences, associate professor, sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: ol.vodopjanova@yandex.ru
Semenova Elena Fedorovna, Candidate of biological sciences, senior researcher, professor, sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: sef1957@mail.ru
Kondrat'ev Ruslan Olegovich, Student, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: kondratev.ruslan1995@yandex.ru 

Index UDK

615.1: 615.015.4.032 

DOI

10.21685/2072-3032-2018-4-8 

Abstract

Background. It is known that psychosocial tension and low level of physical activity play an important role in the development of cardiovascular diseases. In this regard, it is of interest to use as a means of correcting the risk factors of cardiovascular disease drugs that reduce anxiety, but do not reduce the level of physical activity. The purpose of this study the impact of collecting "Stelinol" for survival and the level of locomotor and exploratory activity of white rats with experimental metabolic syndrome.
Materials and methods. The study was conducted on 72 nonlinear white female rats weighing 200–220 g, contained in standard vivarium conditions with free access to water and food. All animal manipulation was carried out in accordance with the rules of the European Convention for the protection of vertebrates used for experimental and other scientific purposes (ETSN 123, Strasbourg, 18 March 1986) and was approved by the local ethics Committee. In experimental metabolic syndrome examined the effects of collecting "Stelinol" on the survival of animals and their locomotor and exploratory activity the method of "open field"
Results. The data obtained in the course of the study can be interpreted as indirect evidence of reducing anxiety and increasing the level of research activity, as well as increasing the survival rate of rats as well as increased survival of rats with experimental metabolic syndrome on the background of the collection "Stelinol".
Conclusion. Collection "Stelinol"enhances exploratory activity, reduces anxiety, and increases the survival of animals in terms of modeling metabolic syndrome. 

Key words

collection "Stelinol", anxiety, survival, "open field» 

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Дата создания: 17.06.2019 13:30
Дата обновления: 17.06.2019 14:39